On April 11, 2012, Madonna's manager Guy Oseary responded to a Madonna fan on Twitter, who was asking for the song to be a single from MDNA. He replied saying the song "is feeling like the next single." The cover art was released on Madonna's official website on July 13, 2012. Before the single was released, Smirnoff released a seven-track digital remix EP titled MDNA: Nightlife Edition Remix EP in the UK to promote the album. It included three remixes of "Turn Up the Radio" by Leo Zero, Richard Vission and Marco V. The mixes by Zero and Vission were also included on the MDNA: Nightlife Edition of the album which was exclusively sold in the US.
The single remix EP was released on August 3, 2012 in Australia and New Zealand, and August 5, 2012 in the United Kingdom. The EP included remixes by Offer Nissim, Martin Solveig and R3hab. Madonna also collaborated with group Far East Movement, who featured on the Laidback Luke remix of the single. The song was serviced to contemporary hit radio in the United States by Interscope, on September 25, 2012.
